Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

As much a portrait of his time as a biography of the man, Karl Marx: Greatness and Illusion returns the author of Das Kapital to his nineteenth-century world, before twentieth-century inventions transformed him into Communism’s patriarch and fierce lawgiver. Gareth Stedman Jones depicts an era dominated by extraordinary challenges and new notions about God, human capacities, empires, and political systems—and, above all, the shape of the future. In the aftermath of the Battle of Waterloo, a Europe-wide argument began (...) about the industrial transformation of England, the Revolution in France, and the hopes and fears generated by these occurrences. Would the coming age belong to those enthralled by the revolutionary events and ideas that had brought this world into being, or would its inheritors be those who feared and loathed it? Stedman Jones gives weight not only to Marx’s views but to the views of those with whom he contended. He shows that Marx was as buffeted as anyone else living through a period that both confirmed and confounded his interpretations—and that ultimately left him with terrible intimations of failure. Karl Marx allows the reader to understand Marx’s milieu and development, and makes sense of the devastating impact of new ways of seeing the world conjured up by Kant, Hegel, Feuerbach, Ricardo, Saint-Simon, and others. We come to understand how Marx transformed and adapted their philosophies into ideas that would have—through twists and turns inconceivable to him—an overwhelming impact across the globe in the twentieth century. (shrink)

In standard interpretations of the history of socialism, the cosmological and providential side of nineteenth century socialist thought tends to be ignored. What still today is often considered the core of socialist reasoning was its preoccupation with the claims of producers, its championing of the cause of the working class, its critique of political economy. In the twentieth century, the most characteristic goal of socialist parties - at least until the advent of Tony Blair - has been the socialisation of (...) the means of production. The particular association of socialism with a language of productivism - with work, producers, the character of labour, and a critique of political economy - goes back to the commentaries of the 1830s and 1840s. Adolphe Blanqui, the brother of the famous revolutionary, in his History of Political Economy in Europe published in 1837, described Fourier and Owen as 'utopian economists',1 while Lorenz von Stein in his Der Sozialismus und Kommunismus des heutigen Frankreichs, first published in 1842, defined socialism as a theory which made work the sole basis of.. (shrink)

Objective: The aim of this study was to examine the psychometric properties and factorial structure of the Schema Mode Inventory for Eating Disorders (SMI-ED) in a disordered eating population. Method: 573 participants with disordered eating patterns as measured by the Eating Disorder Examination Questionnaire (EDE-Q) completed the 190-item adapted version of the Schema Mode Inventory (SMI). The new SMI-ED was developed by clinicians/researchers specializing in the treatment of eating disorders, through combining items from the original SMI with a set of (...) additional questions specifically representative of the eating disorder population. Psychometric testing included Confirmatory Factor Analysis (CFA) and internal consistency (Cronbach’s α). Multivariate Analyses of Covariance (MANCOVA) was also run to test statistical differences between the EDE-Q subscales on the SMI-ED modes, while controlling for possible confounding variables. Results: Factorial analysis confirmed an acceptable sixteen-related-factors solution for the SMI-ED, thus providing preliminary evidence for the adequate validity of the new measure based on internal structure. Concurrent validity was also established through moderate to high correlations on the modes most relevant to eating disorders with EDE-Q subscales. This study represents the first step in creating a psychometrically sound instrument for measuring schema modes in eating disorders, and provides greater insight into the relevant schema modes within this population. Conclusion: This research represents an important preliminary step toward understanding and labeling the schema mode model for this clinical group. Findings from the psychometric evaluation of SMI-ED suggest that this is a useful tool which may further assist in the measurement and conceptualization of schema modes in this population. (shrink)

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Experimental engineering models have been used both to model general phenomena, such as the onset of turbulence in fluid flow, and to predict the performance of machines of particular size and configuration in particular contexts. Various sorts of knowledge are involved in the method - logical consistency, general scientific principles, laws of specific sciences, and experience. I critically examine three different accounts of the foundations of the method of experimental engineering models (scale models), and examine how theory, practice, and experience (...) are involved in employing the method to obtain practical results. Models of machines and mechanisms can be (and generally are) involved in establishing criteria for similar phenomena, which provide guidance in using events to model other events. Conversely, models of phenomena such as events that model other events can be (and generally are) involved in experimentation on models of machines. I conclude that often it is not more detailed models or the more precise equations they engender that leads to better understanding, but rather an insightful use of knowledge at hand to determine which similarity principles are appropriate in allowing us to infer what we do not know from what we are able to observe. (shrink)

In "The Status and Future of the Turing Test" (Moor, 2001), which appeared in an earlier issue of this journal, James Moor remarks on my paper "Turing's Two Tests for Intelligence." In my paper I had claimed that, whatever Turing may or may not have thought, the test described in the opening section of Turing's now legendary 1950 paper "Computing Machinery and Intelligence" is not equivalent to, and in fact is superior to, the test described in a passage that occurs (...) much later in Turing's paper (i.e., in Section 5 of Turing, 1950). I'm pleased Moor chose to give such prominence to my point, and very happy to see that he recognized that my claim was a normative one about the superiority of one test over another, rather than a claim about Turing's intentions. However, as I think the way he describes my point could lead to misunderstandings, I'd like to clarify the points I made. One major clari?cation is which two tests I am contrasting; another is that the difference in overall structure of the two tests is of philosophical signi?cance. (shrink)

On a literal reading of `Computing Machinery and Intelligence'', Alan Turing presented not one, but two, practical tests to replace the question `Can machines think?'' He presented them as equivalent. I show here that the first test described in that much-discussed paper is in fact not equivalent to the second one, which has since become known as `the Turing Test''. The two tests can yield different results; it is the first, neglected test that provides the more appropriate indication of intelligence. (...) This is because the features of intelligence upon which it relies are resourcefulness and a critical attitude to one''s habitual responses; thus the test''s applicablity is not restricted to any particular species, nor does it presume any particular capacities. This is more appropriate because the question under consideration is what would count as machine intelligence. The first test realizes a possibility that philosophers have overlooked: a test that uses a human''s linguistic performance in setting an empirical test of intelligence, but does not make behavioral similarity to that performance the criterion of intelligence. Consequently, the first test is immune to many of the philosophical criticisms on the basis of which the (so-called) `Turing Test'' has been dismissed. (shrink)

In this essay, I use the theological anthropology of the apostle Paul as a diagnostic lens in order to bring into focus some implicit assumptions about human personhood in the goals and methods of treatment with psychotropic medications. I argue that Paul views the body as a mode of participation in larger relational matrices in both vulnerable and vital ways. He thus sees the self as constituted relationally rather than as fundamentally isolated and self-determining. Such an understanding of personhood yields (...) an account of human agency as co-constituted and freedom as interpersonally mediated and sustained. From this perspective, the proper goal for psychiatric medication is the removal of barriers to life-giving human connections; methods of care for persons in psychological distress may include medication, but they also require embodied personal encounter. (shrink)

This paper investigates the following proposal about machine intelligence: that behaviour in which a habitual response that would have been inappropriate in a certain unfamiliar situation is overridden and replaced by a more appropriate response be considered evidence of intelligence. The proposal was made in an earlier paper (Sterrett 2000) and arose from an analysis of a neglected test for intelligence hinted at in Turing's legendary 'Computing Machinery and Intelligence'; it was also argued there that it was a more principled (...) test of machine intelligence than straightforward comparisons with human behaviour. The present paper first summarizes the previous claim then looks at writings about intelligence, or the lack of it, in animals and machines by various writers (Descartes, Hume, Darwin and James). It is then shown that, despite their considerable differences regarding fundamental things such as what kinds of creatures are intelligent and the relationship between reason, instinct and behaviour, all of these writers would regard behaviour that meets the proposed criterion as evidence of intelligence. Finally, some recent work in employing logic and reinforcement learning in conjunction with 'behaviour-based' principles in the design of intelligent agents is described; the significance for the prospect of machine intelligence according to the proposed criterion is discussed. (shrink)

I examine Frege’s explanation of how Hilbert ought to have presented his proofs of the independence of the axioms of geometry: in terms of mappings between (what we would call) fully interpreted statements. This helps make sense of Frege’s objections to the notion of different interpretations, which many have found puzzling. (The paper is the text of a talk presented in October 1994.).

Summary Analogue models are actual physical setups used to model something else. They are especially useful when what we wish to investigate is difficult to observe or experiment upon due to size or distance in space or time: for example, if the thing we wish to investigate is too large, too far away, takes place on a time scale that is too long, does not yet exist or has ceased to exist. The range and variety of analogue models is too (...) extensive to attempt a survey. In this article, I describe and discuss several different analogue model experiments, the results of those model experiments, and the basis for constructing them and interpreting their results. Examples of analogue models for surface waves in lakes, for earthquakes and volcanoes in geophysics, and for black holes in general relativity, are described, with a focus on examining the bases for claims that these analogues are appropriate analogues of what they are used to investigate. A table showing three different kinds of bases for reasoning using analogue models is provided. Finally, it is shown how the examples in this article counter three common misconceptions about the use of analogue models in physics. (shrink)

Today I want to talk about an element in the milieu in which Ludwig Wittgenstein conceived the Tractatus Logico-Philosophicus that has not been recognized to date: the generalization of the methodology of experimental scale models that occurred just about the time he was writing it. I find it very helpful to keep in mind how this kind of model portrays when reading the Tractatus — in particular, when reading the statements about pictures and models, such as:That a picture is a (...) fact ,That a picture is a model of reality ,That the “pictorial relationship” that makes a picture a picture is part of that picture , andThat a picture must have its pictorial form in common with reality in order to able to depict it. (shrink)

The concept of similar systems arose in physics, and appears to have originated with Newton in the seventeenth century. This chapter provides a critical history of the concept of physically similar systems, the twentieth century concept into which it developed. The concept was used in the nineteenth century in various fields of engineering, theoretical physics and theoretical and experimental hydrodynamics. In 1914, it was articulated in terms of ideas developed in the eighteenth century and used in nineteenth century mathematics and (...) mechanics: equations, functions and dimensional analysis. The terminology physically similar systems was proposed for this new characterization of similar systems by the physicist Edgar Buckingham. Related work by Vaschy, Bertrand, and Riabouchinsky had appeared by then. The concept is very powerful in studying physical phenomena both theoretically and experimentally. As it is not currently part of the core curricula of STEM disciplines or philosophy of science, it is not as well known as it ought to be. (shrink)

This paper presents a theoretical elaboration of the ethical framework of classical capitalism as formulated by Adam Smith in reaction to the dominant mercantilism of his day. It is seen that Smith's project was profoundly ethical and designed to emancipate the consumer from a producer and state dominated economy. Over time, however, the various dysfunctions of a capitalist economy — e.g., concentration of wealth, market power — became manifest and the utilitarian ethical basis of the system eroded. Contemporary capitalism, dominated (...) as it is by large corporations, entrenched political interests and persistent social pathologies, bears little resemblance to the system which Smith envisioned would serve the common man. Most critiques of capitalism are launched from a Marxian-based perspective. We find, however, that by illustrating the wide gap between the reality of contemporary capitalism and the model of amoral political economy developed by Smith, the father of capitalism proves to be the most trenchant critic of the current order. (shrink)

This chapter describes discussions by scientists in Wittgenstein’s milieu relevant to problems Wittgenstein was pondering after he had decided to devote himself to solving the problems of logic. The chapter opens just after his father has died, and Wittgenstein’s investigations into logic were bringing him to examine notions of mirroring and corresponding. It discusses Ludwig Boltzmann’s views on differential equations, mental models, experimental models, and debates with Ostwald on the use of models in the kinetic theory of gases. Work on (...) similarity by various scientists developed from insights by Newton and Galileo is surveyed. Questions about equations analogous to those Wittgenstein was pondering about propositions in early 1914 would receive an answer by the end of 1914—by a physicist who had studied thermodynamics with Ostwald, and formalized the concept of “physically similar systems.”. (shrink)

This is the text of Dr. Sterrett's replies to an interviewer's questions for simplycharly.com, a website with interviews by academics on various authors, philosophers, and scientists.

Toys to overcome time, distance, and gravity -- To fly like a bird, not float like a cloud -- Finding a place in the world -- A new continent -- A new age-old problem to solve -- The physics of miniature worlds -- Models of wings and models of the world -- A world made of facts.